Siegfried Labeit Selected Research

nebulin

6/2013	Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.
1/2013	Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency.
1/2012	The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization.
3/2011	Nebulin, a major player in muscle health and disease.
11/2009	Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost.
7/2009	Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency.
7/2003	Nebulin: the nebulous, multifunctional giant of striated muscle.

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Siegfried Labeit Research Topics

Disease

14	Atrophy 12/2020 - 01/2005
13	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 07/2020 - 02/2002
12	Heart Failure 10/2020 - 09/2002
8	Muscular Diseases (Myopathy) 01/2022 - 07/2003
7	Hypertrophy 06/2022 - 11/2003
7	Muscle Weakness 06/2013 - 02/2003
6	Nemaline Myopathies (Nemaline Myopathy) 06/2013 - 07/2009
5	Cardiomyopathies (Cardiomyopathy) 09/2016 - 09/2009
5	Muscular Dystrophies (Muscular Dystrophy) 01/2014 - 02/2004
5	Limb-girdle muscular dystrophy type 2A 08/2010 - 01/2004
4	Muscular Atrophy (Muscle Atrophy) 01/2022 - 10/2013
4	Heart Diseases (Heart Disease) 05/2015 - 12/2002
3	Fibrosis (Cirrhosis) 01/2022 - 09/2009
3	Neoplasms (Cancer) 10/2020 - 10/2013
3	Cachexia 01/2020 - 10/2013
3	Critical Illness (Critically Ill) 05/2015 - 01/2014
3	Starvation 06/2008 - 11/2003
2	Sudden Death 02/2013 - 08/2011
2	Ischemia 01/2013 - 02/2004
2	Cardiomegaly (Heart Hypertrophy) 09/2009 - 02/2007
2	Autolysis 05/2008 - 07/2006
1	Polyps 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 10/2020
1	Pulmonary Hypertension 01/2020
1	Atherosclerosis 01/2020
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 11/2019
1	Infarction (Infarctions) 10/2019
1	Myocardial Infarction 10/2019
1	Myasthenia Gravis 01/2016
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2016
1	Thymoma (Thymic Carcinoma) 01/2016
1	Chorea (Rheumatic Chorea) 01/2016
1	Breast Neoplasms (Breast Cancer) 01/2016
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2016
1	subacute Cerebellar degeneration 01/2016
1	Sarcopenia 01/2014
1	Renal Insufficiency (Renal Failure) 10/2013
1	Acquired Immunodeficiency Syndrome (AIDS) 10/2013
1	Heart Arrest (Cardiac Arrest) 02/2013
1	Restrictive Cardiomyopathy 05/2012
1	Disease Progression 01/2012
1	Cardiac Sudden Death (Sudden Cardiac Arrest) 08/2011
1	Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy) 08/2011
1	Inborn Genetic Diseases (Disease, Hereditary) 08/2010
1	Familial Hypertrophic Cardiomyopathy (Cardiomyopathy, Familial Hypertrophic) 01/2010

Drug/Important Bio-Agent (IBA)

30	ConnectinIBA 01/2022 - 02/2002
24	Proteins (Proteins, Gene)FDA Link 06/2022 - 02/2002
7	UbiquitinIBA 01/2022 - 06/2008
7	nebulinIBA 06/2013 - 07/2003
6	Muscle Proteins (Muscle Protein)IBA 01/2020 - 02/2004
4	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2022 - 05/2015
4	Peptide Hydrolases (Proteases)FDA Link 08/2010 - 01/2004
4	Protein Isoforms (Isoforms)IBA 01/2007 - 09/2002
3	Ligases (Synthetase)IBA 01/2022 - 06/2008
3	CalpainIBA 08/2010 - 01/2005
2	Leucine (L-Leucine)FDA Link 12/2020 - 01/2017
2	MicroRNAs (MicroRNA)IBA 01/2020 - 03/2017
2	EnzymesIBA 01/2020 - 10/2019
2	MonocrotalineIBA 01/2020 - 12/2017
2	AntibodiesIBA 01/2016 - 06/2008
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2014 - 10/2013
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 10/2013 - 12/2008
2	ElementsIBA 01/2013 - 09/2009
2	Crystallins (Crystallin)IBA 05/2009 - 02/2004
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2008 - 01/2007
1	GelatinasesIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	Matrix Metalloproteinases (MMPs)IBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 02/2021
1	Peptides (Polypeptides)IBA 01/2021
1	Histone Deacetylases (Histone Deacetylase)IBA 12/2020
1	MyostatinIBA 11/2020
1	Citrate (si)-Synthase (Synthase, Citrate)IBA 10/2020
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2020
1	Pharmaceutical PreparationsIBA 10/2020
1	Histone Deacetylase InhibitorsIBA 07/2020
1	Dexamethasone (Maxidex)FDA LinkGeneric 12/2017
1	TransferasesIBA 03/2017
1	Amino Acids FDA Link 01/2017
1	anti-titin autoantibodyIBA 01/2016
1	AdiponectinIBA 01/2015
1	Myosins (Myosin)IBA 04/2014
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 04/2014
1	Amyloid (Amyloid Fibrils)IBA 01/2014
1	Interleukin-6 (Interleukin 6)IBA 01/2014
1	AgrinIBA 01/2014
1	Cholinergic ReceptorsIBA 10/2013
1	KN 93IBA 01/2013
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2013
1	Mutant Proteins (Protein, Mutant)IBA 08/2010
1	Carrier Proteins (Binding Protein)IBA 01/2010
1	Cardiac MyosinsIBA 01/2010
1	SuspensionsIBA 01/2010

Therapy/Procedure

6	Denervation 10/2018 - 11/2003
2	Therapeutics 03/2015 - 09/2009
2	Heart Transplantation (Grafting, Heart) 03/2015 - 08/2011
1	Ligation 10/2019
1	Length of Stay 05/2015
1	Artificial Respiration (Mechanical Ventilation) 05/2015
1	Mechanical Ventilators (Ventilator) 05/2015